Hello Everyone, Happy New Year!!
It’s my great pleasure to announce that we are returning with our weekly meetings for the Math-Bio seminar! As a reminder, these meetings will be happening every Wednesday at 2:00 pm (Pacific Time) in the PIMS lounge (ESB 4133). PIMS tea will follow the seminar at around 3:00 pm.
For our return on Wednesday, January 14th, our speaker will be Puneet Velidi a graduate student from UVIC. This presentation will happen remotely with our usual watch party. Below, more information about this exciting talk.
For those unable to attend in person, you can join via Zoom using the link below.
I hope to see you all there!
Join Zoom Meeting:
https://ubc.zoom.us/j/65246006268?pwd=vFrUpDrzPEYGZ3dSezvCp2uiupsdiO.1
Meeting ID: 652 4600 6268
Passcode: 988036
Advances in protein folding and structure prediction models have enabled new computational approaches to immunotherapeutic research by providing access to high-quality structural information at scale. In this talk, we present three core application areas. (1) Antigen structure prediction, where folding models are used to characterize the three-dimensional structure of viral, tumor-associated, and neoantigen targets in the absence of experimental data. (2) Antibody–antigen complex prediction, where multimeric and joint modeling approaches are leveraged to infer binding modes, paratope–epitope interactions, and structural determinants of specificity. (3) Immunogenicity prediction, where predicted structures are analyzed to assess surface accessibility, conformational stability, and geometric features that influence immune recognition. Together, these applications illustrate how protein folding models function not only as structure predictors, but as foundational components in quantitative pipelines for immunotherapeutic discovery and design.