geoff

I'm interested in the interplay between theory and experiment in natural science. New measurement technologies like single-cell RNA sequencing are bringing ‘big data’ to biology. My group develops mathematical tools for analyzing time-courses of high-dimensional gene expression data, leveraging tools from optimal transport, at the intersection of probability, statistics, and optimization. With the theory we develop, we aim to answer questions like: How does a stem cell transform into a muscle cell, a skin cell, or a neuron? How can we reprogram a skin cell into a neuron?