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UBC Math Dept
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Mathematical Biology and related seminars

January, 2021
Wednesday,
January 27
Cole Zmurchok -- 2:05 pm in Zoom
Vanderbilt University
Mechanosensing can enhance adaptation to maintain polarity of migrating cells
Abstract
Migratory cells are known to adapt to environments that contain wide-ranging levels of chemoattractant. While biochemical models of adaptation have been previously proposed, here we discuss a different mechanism based on mechanosensing, where the interaction between biochemical signaling and cell tension facilitates adaptation. In this talk, we develop and analyze a model of mechanochemical-based adaptation consisting of a mechanics-based physical model coupled with the wave-pinning reaction-diffusion model for Rac GTPase activity. We use Local Perturbation Analysis to predict how cells adapt signaling parameters via feedback from mechanics to maintain polarity in response to chemoattractant levels. To confirm this prediction, we simulate the mechanochemical model in moving cells, demonstrating how mechanosensing results in persistent cell polarity when cells are stimulated with wide-ranging levels of chemoattractant in silico. These results demonstrate how mechanosensing may help cells adapt to maintain polarity in variable environments.
February, 2021
Wednesday,
February 3
Abby Kindberg -- 2:05 pm in Zoom
UCSF
TBA
Abstract
TBA
Wednesday,
February 10
John Lowengrub -- 2:05 pm in Zoom
UCI
TBA
Abstract
TBA
Wednesday,
February 24
Veronica Ciocanel -- 2:00 pm in Zoom
Duke University
Modeling and topological data analysis for biological ring channels
Abstract
TBA
April, 2021
Wednesday,
April 21
Kenji Sugioka -- 2:05 pm in Zoo
UBC Zoology
TBA
Abstract
TBA

Seminar series sponsored by PIMS.

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