The interplay between mechanics and Rho-family GTPase signalling
As cells change shape, migrate individually or collectively, they experience forces from their environment and neighbours. These forces are translated into chemical signals that regulate GTPase signalling, thus providing a feedback mechanism. Using ODE and cell-based models, we explore the implications on feedback from tension to GTPase activity on the behaviour of a multicellular group.
- Cole Zmurchok et al 2018 Phys. Biol. in press https://doi.org/10.1088/1478-3975/aab1c0