Last updated: May 2011

- Understanding Complex Systems. Synergy 5.1 (UBC Faculty of Science publication), December 1999.

- Lee A Segel and Leah Edelstein-Keshet (2010) Perspectives on Mathematical Biology; (under review for SIAM; 427pp). [An expanded version of a book
project that Lee Segel was developing before he passed away.]
- Edelstein-Keshet, L (2005) Adapting mathematics to the new biology, Chapter in Math & Bio 2010; Linking Undergraduate Disciplines, Lynn A Steen, Ed, Mathematical Association of America (MAA).
- Edelstein-Keshet, L (2005; originally 1988) Mathematical Models in Biology,
reprinted by SIAM under the "classics" editions.

Link to the SIAM book webpage.

Other details on my site. - Okubo, A,
Grunbaum, D, Edelstein-Keshet, L (2001) The Dynamics of Animal Grouping,
Chapter 7 in: A Okubo and S Levin,
Diffusion and Ecological Problems: Modern Perspectives,
Springer Verlag, NY
- Leah Edelstein-Keshet: Nature or Nurture? My Mathematical Biology Upbringing AAAS Highwire Press, ScienceCareers.org Feb 20, 2004.

- Jilkine A, Edelstein-Keshet L (2011) A Comparison of Mathematical Models for Polarization of single eukaryotic cells in response to guided cues, (Review), PLOS Computational Biology 7 (4):e1001121, April 28, 2011. Link to PLOS paper
- Tania N, Prosk E, Condeelis J, Edelstein-Keshet L (2011) A temporal model of cofilin regulation and the early peak of actin barbed ends in invasive tumor cells, Biophys J 100, 1883-1892,Link to Journal , P.,
Sup..
- Mori Y, Jilkine A, Edelstein-Keshet L (2010) Asymptotic and bifurcation analysis of wave-pinning in a reaction-diffusion model for cell polarization, under review, SIAM J Applied Math.
Link to ArXiv
- Vanderlei B, Feng J, Edelstein-Keshet L. (2010) A computational model of cell polarization and motility coupling mechanics and biochemistry, submitted. Link to ArXiv
- Green JEF, Waters SL, Whiteley JP, Edelstein-Keshet L, Shakesheff KM, Byrne HM (2010) Non-local models for the formation of hepatocyte-stellate cell aggregates, J Theor Biol 267 (1): 106-120. Link .
- Lukeman R, Li YX, Edelstein-Keshet L (2010) How do ducks line up in rows: inferring individual rules from collective behaviour, PNAS 107 (28): 12576-12580. Link.

This paper was featured in a short editorial in Nature 466:163 (July 8, 2010) and on the cover of the AMS Notices, in April 2011 - Das R, Nachbar R, Saltzman J, Bagchi A, Bailey J, Edelstein-Keshet L, Coombs D, Cook J, Hargreaves R, Simon A (2010) Modeling effect of a gamma-secretase inhibitor on amyloid-beta dynamics reveals significant role of an amyloid clearance mechanism, Bull Math Biol. 73(1): 230-247.
Link to Journal
- Khadra A, Tsai, Santamaria P, Edelstein-Keshet L, (2010) On how monospecific memory-like autoregulatory CD8+ T cells can blunt diabetogenic autoimmunity: a computational approach. Journal of Immunology 185: 5962-5972.
Link to Anmar's Publications
- Khadra A, Santamaria P, Edelstein-Keshet L (2010) The pathogenicity of self-antigen decreases at high levels of autoantigenicy: a computational approach, International Immunology 22 (7), 571-852. Link to Anmar's Publications
- Khadra A, Santamaria P, Edelstein-Keshet L (2008) The role of low avidity T cells in the protection against Type 1 Diabetes: a modeling investigation, J theor biol 256 (1): 126-141.Link to Anmar's Publications
- Lukeman R, Li Y X, Edelstein-Keshet L (2008) A conceptual model for milling formations in biological aggregates, Bull Math Biol. 71(2): 352-382
Preprint
- Mori Y, Jilkine A, Edelstein-Keshet L (2008) Wave-pinning and cell polarity from a bistable reaction-diffusion system, Biophysical Journal 94(9): 3684-3697. Preprint and Supplementary material
- Maree AFM, Komba M, Finegood D, Edelstein-Keshet L(2008) A quantitative comparison
of rates of phagocytosis and digestion of apoptotic cells by macrophages
from normal (BALB/c) and diabetes-prone (NOD) mice, Journal of Applied Physiology 104(1): 157-169 Preprint.
- Li YX, Lukeman R, Edelstein-Keshet L (2008) Minimal mechanisms for school formation in self-propelled particles, Physica D 237 (5):699-720.
- Dawes AT, Edelstein-Keshet L (2007) Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a 1D model of a motile cell, Biophysical Journal 92: 1-25 (February) (Uncorrected proofs).
- Jilkine A, Maree AFM, Edelstein-Keshet L (2007) Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk, Bull Math Biol 68(5):1169-1211 Preprint
- Mahaffy JM, Edelstein-Keshet L (2007) Modeling cyclic waves of circulating T-cells in autoimmune diabetes, SIAM J Applied Math (SIAP) 67(4): 915-937Preprint.
- Maree AFM, Jilkine A, Dawes AT, Greineisen VA, Edelstein-Keshet L (2006) Polarization and movement of keratocytes: a multiscale modelling approach. Bull Math Biol, 68(5):1169-1211. Preprint. You can also see Movies on Stan's website.
- Maree AFM, Santamaria P, Edelstein-Keshet L (2006) Modeling competition among CD8+ T cells in autoimmune diabetes: implications for antigen-specific
therapy. International Immunology, 18(7): 1067-1077 reprint.
- Dawes AT, Ermentrout GB, Cytrynbaum EN, Edelstein-Keshet L (2006) Actin filament branching and protrusion velocity in a simple 1D model of a motile cell, J theor Biol 242(2):265-279. reprint
- Gutenkunst R, Newlands N, Lutcavage M, Edelstein-Keshet L (2006) Inferring resource distributions from Atlantic bluefin tuna movements: an analysis based on net displacement and length of track, J theor Biol 245(2): 243-257.Preprint.
- Maree AFM, Kublik R, Finegood DT, Edelstein-Keshet L (2006) Modelling the onset of Type 1 Diabetes: can impaired macrophage phagocytosis make the difference between health and disease? Philosophical Transactions of the Royal Society A, 364, 1267-1282. reprint
- Han B, Serra P, Amrani A Yamanouchi J, Maree AFM, Edelstein-Keshet L, Santamaria P (2005) Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide. Nature Medicine (June) 11 (6): 645-652.reprint
- Maree AFM, Komba M, Dyck C, Labecki M, Finegood DT, Edelstein-Keshet L (2005) Quantifying macrophage defects in type 1 diabetes. J theor Biol (April 21) 233(4): 533-551. reprint
- Mogilner A, Edelstein-Keshet L, Bent L, Spiros A (2003)
Mutual interactions, potentials, and individual distance
in a social aggregation, J Math Biol 47(4): 353-389.
reprint
- Luca M, Chavez-Ross A, Edelstein-Keshet L, Mogilner A (2003)
Chemotactic signalling, microglia, and Alzheimer's disease senile
plaques: is there a connection? Bull Math Biol 65: 693-730.
reprint
- Mogilner A, Edelstein-Keshet L (2002) Regulation of Actin Dynamics
in Rapidly moving cells: A quantitative analysis. Biophys. J. 83: 1237-1258.
reprint

Note: Typo on p1254: col 1, middle of pg: k_{-3} and k_{3}: the coefficients k^{pt} and k^t should be interchanged. - Edelstein-Keshet L, Spiros A (2001) Exploring the formation
of Alzheimer's Disease senile plaques
in Silico , J theor Biol. 216: 301-326. reprint - Edelstein-Keshet L, Israel A, Lansdorp P (2001)
A modeller's perspectives on aging:
Can Mathematics help us stay young? J theor Biol 213 (4):
325-355. reprint
- Edelstein-Keshet, L and Ermentrout, G B (2001) A model
for actin filament length distribution in a lamellipod.
J Math Biol. 43 (4):325-355 reprint
- Edelstein-Keshet, L., and G.B. Ermentrout (2000) Models for the
spatial polymerization dynamics of rod-like polymers,
J. Math. Biol.,
40 (1), 64-96. reprint
- Parrish, J. and Edelstein-Keshet, L. (1999)
Complexity, Pattern, and Evolutionary Trade-offs in Animal Aggregation,
Science, 284 (April 2). Reprint in PS format
- Mogilner A, Edelstein-Keshet L (1999) A non-local model for a swarm,
J. Math Biology, 38:534-570. reprint
- Edelstein-Keshet, L. (1998) Mathematical
approaches to cytoskeletal assembly, European Biophysics Journal 27:521-531.
reprint
- Edelstein- Keshet, L. J. Watmough, and D. Grunbaum (1998) Do traveling
band solutions describe cohesive swarms? An investigation for migratory
locusts, J. Math. Biol., 36, 515-549. reprint
- Spiros, A., and Edelstein-Keshet, L. (1998) Testing a model for the
dynamics of actin structures with biological parameter values,
Bull. Math. Biol., 60 (2), 275-305. reprint
- Edelstein-Keshet, L. and G.B. Ermentrout (1998) Models for the
length distribution of actin filaments I: Simple polymerization and
fragmentation, Bull. Math. Biol 60(3), 449-475. reprint
- Ermentrout, G.B. and L. Edelstein-Keshet (1998) Models for the
length distribution of actin filaments II: Polymerization and fragmentation
by gelsolin acting together, in press, Bull. Math. Biol 60(3), 477-503.
reprint
- Dukas, R. and Edelstein-Keshet, L. (1998) The spatial distribution of
colonial provisioners, J. Theor. Biol. 190, 121-134.
reprint
- Mogilner, A. Edelstein-Keshet, L. and G.B. Ermentrout (1996) Selecting a
common direction: II. Peak-like solutions representing total alignment of
cell clusters, J. Math. Biol., 34, 811-842.
reprint
- Mogilner, A. and Edelstein-Keshet, L. (1996) Spatio-angular order in
populations of self-aligning objects: formation of oriented patches.
Physica D 89, 346-367.reprint
- Mogilner, A and Edelstein-Keshet, L. (1995) Selecting a common
direction: I: how orientational order can arise from simple contact
responses between interacting cells. J. Math. Biol. 33; 619-660
reprint
- Edelstein-Keshet, L., Watmough, J. and G.B. Ermentrout (1995)
Trail-following in social insects: Individual Properties determine
population behaviour. Behavioral Ecology and Sociobiology 36(2), 119-133. reprint
- Watmough, J. and Edelstein-Keshet, L. (1995) A one dimensional model
of trail propagation by army ants. J. Math. Biol., 33, 459-476.
reprint
- Watmough, J. and Edelstein-Keshet, L. (1995) Modelling the Formation
of trail networks by foraging ants. J. Theor. Biol., 176, 357-371.
reprint
- Edelstein-Keshet, L. (1994) Simple models for Trail following behaviour;
trunk trails versus individual foragers, J. Math. Biol. 32:303-328.
reprint
- Civelecoglu, G. and Edelstein-Keshet, L. (1994) Modelling the
dynamics of F-Actin in the cell, Bull. Math. Biol. 56 (4), 587-616.
reprint
- Ermentrout, G.B., Edelstein-Keshet, L. (1993) Cellular automata
approaches to biological modelling, J. Theor. Biol., 160 (1), 97-133.
reprint
- Crenshaw, H. and Edelstein-Keshet, L. (1993) Orientation by helical motion- II, Changing the direction of the axis of motion, Bull. Math. Biol., 55 (1), 213-230. reprint
- Edelstein-Keshet, L.(1991) Heat therapy for tumors, UMAP Journal Vol. 12,
(2), 113-142.
- Edelstein-Keshet, L., G.B. Ermentrout (1990) Models for contact mediated
pattern formation: cells that form parallel arrays, J. Math. Biol. 29:
33-58.reprint
- Edelstein-Keshet, L., and G.B. Ermentrout (1990) Contact responses of
cells can mediate morphogenetic pattern formation, Differentiation: 45 (3),
147-159.
- Edelstein-Keshet L (1986) Mathematical theory for plant-herbivore systems, J Math Biol 24: 25-58. reprint

- Edelstein-Keshet, L (2001) Mathematical models of swarming and social aggregation, invited lecture; The 2001 International Symposium on Nonlinear Theory and its Applications, (NOLTA 2001) Miyagi, Japan (Oct 28-Nov 1, 2001) Preprint in PDF form

Back to my home page.