Mathematics of Information Technology and Complex Systems

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Last updated: Nov 1, 2006

Link to publications from previous years.

Publications from 2005-2006

Articles Published in Refereed Publications

Bernard S, Cajavek B, Pujo-Menjouet L, Mackey MC, Herzel H (2006) Modeling transcriptional feedback loops: The role of Gro/TLE1 in Hes1 oscillations, Phil. Trans. R. Soc. A 364: 1155-1170.

Cytrynbaum EN, Rodionov V, Mogilner A (2006) Nonlocal mechanism of self- organization and centering of microtubule asters. Bull Math Biol, 68:1053-1072.

Dawes AT, Ermentrout GB, Cytrynbaum EN, Edelstein-Keshet L (2006) Actin filament branching and protrusion velocity in a simple 1D model of a motile cell, J. theor. Biol. 242 (2): 265-279.

Dawes AT, Edelstein-Keshet L (2006) Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a 1D model of a motile cell, Biophys J., accepted for publication.

Foley C, Bernard S, Mackey MC (2006) Cost-effective G-CSF therapy strategies for cyclical neutropenia: Mathematical modelling based hypotheses, J. Theor. Biol. 238: 754-763.

Gilchrist MA, Coombs D (2006) Evolution of virulence: Interdependence, constraints and selection using nested models. Theor. Pop. Biol. 69:145-153

Glover CH, Marin M, Eaves CJ, Helgason CD, Piret JM, Bryan J (2006) meta-analysis of mouse embryonic stem cell gene expression kinetics reveals consistent early change of a small gene set under differentiating conditions, PLoS Computational Biology, in press.

He X, Coombs D, Myszka DG, Goldstein B, (2006) Competition between solution and surface receptors for ligand: blocking rebinding during dissociation in a Biacore flow cell. Bull. Math. Biol. 68(5) :1125-1150.

Khadra A, Li YX (2006a) A Model for the Pulsatile Secretion of Gonadotropin-Releasing Hormone from Synchronized Hypothalamic Neurons, Biophysical Journal, 91:74-83.

Maree AFM, Kublik R, Finegood DT, Edelstein-Keshet L (2006) Modelling the onset of Type 1 Diabetes: can impaired macrophage phagocytosis make the difference between health and disease? Philosophical Transactions of the Royal Society A, 364, 1267-1282.

Maree AFM, Santamaria P, Edelstein-Keshet L (2006) Modeling competition among CD8+ T cells in autoimmune diabetes: implications for antigen-specific therapy. International Immunology 18(7): 1067 - 1077.

Maree AFM, Jilkine A, Dawes AT, Edelstein-Keshet L (2006) Polarization and movement of keratocytes: a multiscale modelling approach. Bull. Math. Biol 68 (5): 1169-1211.

Mackey MC, Ou C, Pujo-Menjouet L, Wu J. (2006) Periodic oscillations of blood cell populations in chronic myelogenous leukemia, SIAM J. Math. Anal. 38(1): 166-187.

Mackey MC*, Tyran-Kaminska M (2006) Deterministic Brownian motion: the effects of perturbing a dynamical system by a chaotic semi-dynamical system, Physics Reports 422: 167-222.

Mackey MC*, Tyran-Kaminska M (2006) Noise and conditional entropy evolution. Physica A 365: 360-382.

Mackey MC*, Tyran-Kaminska M (2006) Temporal behaviour of the conditional and Gibbs' entropies, J Stat Phys 124.(online)

O'Brien BA, Geng X, Orteu CH, Huang Y, Ghoreishi M, Zhang Y, Bush JA, Li G, Finegood DT, Dutz JP (2006) A deficiency in the in vivo clearance of apoptotic cells is a feature of the NOD mouse. J. Autoimmun. 26: 104-115.

Utzny C, Coombs D, Muller S, Valitutti S (2006) Analysis of peptide/MHC induced TCR downregulation: deciphering the triggering kinetics, Cell Biochemistry and Biophysics 46:101-112.

* NOTE: These papers arose from research motivated by questions about irreversibility that grew out of work on gene regulatory networks. Hence they are listed here as MITACS-related publications.

Other published refereed contributions

Finegood DT, Komba M, Atkinson L (2006) Apoptosis, phagocytosis and beta- cell directed Autoimmunity. In: Commentaries on Perspectives in Diabetes. Vol 3. Robertson RP, editor, in press.

Published non-refereed contributions:


Colleen Ball, MSc thesis (UBC) 2006 Understanding pathogen selection pressures at the within and between-host levels. (Supervisor: Coombs)

Arshad Chaudhry, Ph.D. Thesis (UBC) 2006 Analysis of stem and progenitor cell responses to variations in bioprocess culture variables. (Supervisor: Piret)

Adriana Dawes, PhD Thesis (UBC) 2006, Phosphoinositides and Rho Proteins Conspire to Spatially Regulate Actin Polymerization in Motile Cells. (supervisor: Keshet)

Published Abstracts:

Colleen Ball (2005) Modeling Virus Competition Dynamics Within a Single Host. American Society for Cell Biology Annual Meeting, San Francisco, CA (December 2005).

Omer Dushek (2005) Modeling TCR Mobility and T Cell Repolarization. American Society for Cell Biology Annual Meeting, San Francisco, CA (December 2005).

Raibatak Das (2005) Automated Real-Time Image Cross-Correlation Analysis of Mast Cell Signaling Reveals Detailed Dynamics of Early Signaling Events. American Society for Cell Biology Annual Meeting, San Francisco, CA (December 2005).

Articles Submitted to Refereed Publications

Ball CL, Gilchrist MA, Coombs D. (2006) Modeling within-host evolution of HIV: Mutation, competition and strain replacement. Submitted.

Coombs D, Ball CL, Gilchrist MA (2006) Resolving the importance of within- and between-host selection pressures on pathogen evolution. Submitted.

Cytrynbaum EN, Marshall B (2006) A Polymer Model Explains MinDE Dynamics in E. coli Cell Division. Biophys J, submitted.

Colijn C, Fowler AC, Mackey MC (2005) High frequency spikes in long period blood cell oscillations, J. Math. Biol., submitted.

Colijn C, Mackey MC (2005) Bifurcation and bistability in a model of hematopoietic regulation, SIAM J. App. Dynam. Sys., submitted.

Dushek O, Coombs D (2006) Improving parameter estimation for cell surface FRAP data. Submitted.

Jilkine A, Maree AFM, Edelstein-Keshet L (2006) Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk, submitted

Khadra A, Li YX (2006b) Robust rhythmogenesis in endocrine neurons via autocrine regulations in a common pool of extracellular hormone, submitted to the Journal of Neuroscience.

Lei J, Mackey MC (2006) Moment stability of stochastic differential delay equations, SIAM Journal of Applied Mathematics, submitted.

Mahaffy JM, Edelstein-Keshet L (2006) Modeling cyclic waves of circulating T-cells in autoimmune diabetes, submitted.

In preparation:

Khadra A, Li YX, Stability analysis of synchronized secretion of GnRH hormone by Coupled Hypothalamic Neurons, under preparation.

Konorov, SO, Glover CH, Piret, JM, Schulze, HG, Blades, MW, Turner, RFB (2006). In Situ Coherent Anti-Stokes Raman Microscopy of Living Embryonic Stem Cells, 95% complete

Lu M, Glover CH, Humphries RK, Piret JM, Helgason CD (2005) The role of c-kit in maintaining murine embryonic stem cells, 90% complete

Chaudhry MAS, Bowen BD, Eaves CJ, Piret JM (2005) Medium pH and osmolality influence the proliferation and differentiation responses of murine embryonic stem cells, to be submitted to Biotechnology & Bioengineering, 80% complete

Chaudhry MAS, O'Connor M, Bowen BD, Eaves CJ, Piret JM, Basal medium and serum substitutes influence the proliferation and differentiation of murine embryonic stem cells, to be submitted to Biotechnology Progress, 90% complete