Formation of a composite material that constitutes bone tissue is a tightly regulated and highly non-linear process. Bone-forming osteoblasts first deposit an extracellular matrix (osteoid) that contains collagenous and noncollagenous proteins that require assembly and maturation. After an initial lag phase, when osteoid is present but no mineralization is evident − a fast primary mineralization occurs, which later turns into a secondary mineralization characterized by a continuous slow increase in bone mineral content. I will describe our studies aimed at development and validation of a mathematical model describing the dynamics of bone mineralization and the roles of individual processes in generating normal and abnormal mineralization patterns. Finally, I will discuss an algorithm for predicting the potential functions for a mutated protein based on the histology of pathologic bone samples from mineralization disorders of unknown etiology.