Daniel Coombs Research Interests
Immune cell signaling and its consequences
Immune cell signaling.
Cell-surface receptor motility and cell-surface dynamics.
T and B cell immune synapse.
Immunoadhesin/antibody-mediated cell adhesion.
Spatial localization of B cell signaling proteins.
Multiscale infectious disease models
Understanding the selective pressures on infectious diseases arising
from competition at the within-host and between-host levels.
Applications to evolution of chronic viral disease.
Metapopulation (patch/network) epidemic modeling.
Applications to human disease
HIV virus dynamics - mutation, recombination and selection in vitro
and in vivo.
Immunodominance in Type 1 diabetes in mice.
Amyloid polymerization and clearance (related to diabetes and
Alzheimer's disease).
Improving biophysical parameter measurement
Understanding and improving binding kinetic measurement with
BIAcore (surface plasmon resonance).
FRAP (fluorescence recovery after photobleaching) analysis for the
mobility of cell-surface proteins.
Fitting single-particle-tracking (SPT) data for cell-surface
proteins to more complex models.