Daniel Coombs Research Interests

Immune cell signaling and its consequences

  • Immune cell signaling.
  • Cell-surface receptor motility and cell-surface dynamics.
  • T and B cell immune synapse.
  • Immunoadhesin/antibody-mediated cell adhesion.
  • Spatial localization of B cell signaling proteins.

    Multiscale infectious disease models

  • Understanding the selective pressures on infectious diseases arising from competition at the within-host and between-host levels.
  • Applications to evolution of chronic viral disease.
  • Metapopulation (patch/network) epidemic modeling.

    Applications to human disease

  • HIV virus dynamics - mutation, recombination and selection in vitro and in vivo.
  • Immunodominance in Type 1 diabetes in mice.
  • Amyloid polymerization and clearance (related to diabetes and Alzheimer's disease).

    Improving biophysical parameter measurement

  • Understanding and improving binding kinetic measurement with BIAcore (surface plasmon resonance).
  • FRAP (fluorescence recovery after photobleaching) analysis for the mobility of cell-surface proteins.
  • Fitting single-particle-tracking (SPT) data for cell-surface proteins to more complex models.

    Daniel Coombs / Department of Mathematics / University of British Columbia
    Last modified: Thu Aug 2 10:18:24 PDT 2007