Overview Topics

Typical chemotaxis coefficient

 Update: 02/20/00

CELL TYPE

CHEMOTAXIS COEFFICIENT

ATTRACTANT

COMMENTS

REF
PMN
leukocytes
8, 10, 60 cm2/s-M = 1,108,360 microns2/min-nM
Not specified

 
Lauffenburger
et al (83)
Neutrophils
(30,130) cm2/s-M =
(180,780) microns2/min-nM
IL-8
(low concentration)

 
Moghe et al (95)
Neutrophils
(1,21) cm2/s-M = (6,126) microns2/min-nM
IL-8
(high concentration)

 
Moghe et al (95)
rabbit PMN
leukocytes
(0,1000) cm2/s-M = (0,6000) microns2/min-nM
FNLLP

 
Rivero et al (89)
Human PMN
Leukocytes
(0,500) cm2/s-M = (0,3000) microns2/min-nM
FNLLP

 
Rivero et al (89)
Microglia
1.65 cm2/s-M = 9.9x10-1 microns2/min-nM
Amyloid-beta
Max response at 10 nM A-beta.
(taxis/kinesis)=2
Davis et al (92)
Monocytes

 
Amyloid-beta
10-25% cells migrate towards A-beta
Fiala et al (98)

[1] Moghe P V, Nelson R D, Tranquillo R T (1995) Cytokine-stimulated chemotaxis of human neutrophils in a 3-D conjoined fibrin assay, J Immunol Meth 180: 193-211.

[2] Rivero M A, Tranquillo R T, Buettner H M, Lauffenburger D A (1989) Transport models for chemotactic cell populations based on individual cell behaviour, Chem Eng Sci 44(12) 2881-2897.

[3] Zigmond S H (1993) Recent quantitative studies of actin filament turnover during cell locomotion, Cell Motil Cytoskel 25: 309-316.

 

[4] Fiala M, Zhang L, Gan X, Sherry B, Taub D, Graves MC, Hama, S, Way D, Weinand M, Witte M, Lorton D, Kuo Y_M, Roher AE (1998) Amyloid-beta induces chemokine secretion and monocyte migration across human blood-brain barrier model, Molec Med 4: 480-489.

[5] Davis JB, McMurray H F, Schubert D (1992), The amyloid beta protein of Alzheimer's disease is chemotactic for mononuclear phagocytes, Biochem Biophys Res Comm 189(2): 1096-1100.