Overview Topics

Summary of Scientific Literature

The following set of pages contain a summary of the scientific literature and consultation with experts, and represents an intermediate stage in which pertinent facts are being collected and assembled. As yet, these features are not detailed enough to be included in the simulation. As further details emerge, these factors will be included in the simulation.

Index of current summaries

Complement

Apolipoprotein E

Alpha-1 antichymotrypsin



Complement, ApoE and alpha-1 antichymotrypsin, are substances that can affect the rate of deposition, aggregation, or processing of amyloid Beta, and thereby affect the formation of plaques in Alzheimer's disease. Follow the links above to see details collected from the literature, and citations of key papers.

According to McGeer and McGeer(1999) [see link] the cells secreting these substances are as follows:

SubstanceCells that secrete
C1-C9
complement
microglia
astrocytes
neurons
C1-Inhibitormicroglia
neurons
alpha1-antichymotrypsinastrocytes
ApoEmicroglia
astrocytes
neurons



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