Neurotoxicity of Microglia

• Klegeris A. McGeer PL.Interaction of various intracellular signaling mechanisms involved in mononuclear phagocyte toxicity toward neuronal cells.Journal of Leukocyte Biology. 67(1):127-33, 2000 Jan.
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• Klegeris A. Walker DG. McGeer PL.Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs).Neuropharmacology. 38(7):1017-25, 1999 Jul.
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• Giulian D, Haverkamp LJ, Li J, Karshin WL, Yu J, Tom D, Li X Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain Neurochemistry Int'l, 27:119-137, 1995.
  
  
• Giulian D, Vaca K, Corpuz M, Brain glia release factors with opposing actions upon neuronal survival J. Neurosci 13:29-37, 1993
  
  
• Giulian D, Haverkamp LJ, Yu J, Karshin W, Tom D, Li J, Kazanskaia A, Kirkpatrick J, Roher AE The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease. J Biol Chem 273(45):29719-29726, 1998 Pub Med Abstract
  
  
• Giulian D, Haverkamp LJ, Yu JY, Karshin W, Tom D, Kirkpatrick J, Kuo Y-M, Roher AE Specific Domains of Beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia, J. Neurosci. 16:6021-6037 1996 JN Abstract