Pellegrini P, Berghella AM, Di Loreto S, Del Beato T, Di Marco F, Adorno D, Casciani CU.
Cytokine contribution to the repair processes and homeostasis recovery following anoxic insult: a possible IFN-gamma-regulating role in IL-1beta neurotoxic action in physiological or damaged CNS, Neuroimmunomodulation 3(4), :213-8, 1996.
Abstract
The cytokine contribution to the central nervous system (CNS) is currently being investigated, but conflicting results have frequently been
found. Since, as stressed in the immune system, the cytokine action can be profoundly influenced by the synergistic and antagonistic
interactions of the various cytokines present in the medium, a productive effect of the cytokine network in the repair processes and
homeostasis recovery may also be dependent on their balanced response in the CNS. We, therefore, hypothesize that it is necessary to
study the cytokine contribution to CNS events, evaluating cytokines both in their network and individually. Recent studies focus on
interleukin 1 (IL-1) as a cytokine of primary importance for the outcome of diseases, and it seems to exert this role by regulating the
synthesis of new proteins such as gamma interferon (IFN-gamma) cytokine which has been reported as having a very important early role in
the balance of interactions in the cytokine network.
Important Points:
-Model: culture
-cytokine release and action depends on the specific context: IFN gamma and IL1 B release covaries positively in physiological conditions, but negatively in anoxic conditions
-IFN is not toxic under physiological conditions, but is under anoxic conditions
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