Makrides, S. C. (1998).
Therapeutic Inhibition of the Complement System. Pharmacological
Reviews 50: 59-88
Abstract
- I. Introduction
- II. The Complement System and Its Regulation
- A. The Classical Pathway
- B. The Alternative Pathway
- C. The Membrane Attack Complex
- III. Modified Native Complement Components That
Block Complement Activation
- A. Soluble Complement Receptor Type 1
- B. Soluble Complement-Receptor Type 1 Lacking
Long Homologous Repeat-A
- C. Soluble Complement Receptor Type 1-Sialyl
Lewisx
- D. Complement Receptor Type 2
- E. Soluble Decay Accelerating Factor
- F. Soluble Membrane Cofactor Protein
- G. Soluble CD59
- H. Decay Accelerating Factor-CD59 Hybrid
- I. Membrane Cofactor Protein-Decay Accelerating
Factor Hybrid
- J. C1 Inhibitor
- K. C1q Receptor
- IV. Complement-Inhibitory Antibodies
- A. Anti-C5 Monoclonal Antibody
- B. Anti-C5 Single Chain Fv
- V. Synthetic Inhibitors of Complement Activation
- A. Peptides and Analogs
- B. Organic Molecules
- VI. Naturally Occurring Compounds That Block
Complement Activation
- VII. Complement Inhibition in Xenotransplantation
- VIII. Bispecific Antibodies for Immune Complex
Removal
IX. Summary
Acknowledgments
References
.
Return to Complement References.