Abbenante G. Kovacs DM. Leung DL. Craik DJ. Tanzi RE. Fairlie DP.Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site.Biochemical & Biophysical Research Communications. 268(1):133-5, 2000 Feb 5.

Abstract

A series of inhibitors of beta-amyloid formation have been developed based on the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein. A simple tripeptide aldehyde was found to be the most potent (IC(50) = 700 nM) in the series displaying an inhibitory profile which is different from reported inhibitors of beta-amyloid formation.



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