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UBC Math Dept
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Mathematical Biology and related seminars

June, 2018
Wednesday,
June 27
Gautam Menon -- 3:15 pm in ESB 4127
IMSC, Chennai
Modeling cell-substrate de-adhesion dynamics under fluid shear
Abstract
Changes in cell-substrate adhesion are believed to signal the onset of cancer metastasis, but such changes must be quantified against background levels of intrinsic heterogeneity between cells. Variations in cell-substrate adhesion strengths can be probed through biophysical measurements of cell detachment from substrates upon the application of an external force. I will describe theoretical and experimental investigations of the detachment of cells adhered to substrates when these cells are subjected to fluid shear. I will present a theoretical framework within which we calculate the fraction of detached cells as a function of shear stress for fast ramps as well as for the decay in the fraction of detached cells at fixed shear stress as a function of time. Using HEK and 3T3 fibroblast cells as experimental model systems, characteristic force scales for cell adhesion as well as characteristic detachment times are extracted. Variations in adhesion across cell types are especially prominent when cell detachment is probed by applying a time-varying shear stress. These methods can be applied to characterizing changes in cell adhesion in a variety of contexts, including metastasis.
September, 2018
Wednesday,
September 19
Nourridine Siewe -- 3:15 pm in ESB 4127
UBC Okanagan
TBA
Abstract
TBA
Thursday,
September 27
Frithjof Lutscher -- 2:00 pm in Math 126
University of Ottawa
TBA
Abstract
TBA

Seminar series sponsored by PIMS.

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